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Sixty elderly men were put on various Ostarine dosages for 3 months, and it was found that simply taking 3mg of Ostarine per day led to an increase in muscle mass by 1%.3.1. InterventionsOn the other hand, there has not been an adequate study comparing the use of Ostarine with a similar supplement (EAA) that contained Arginine, since many studies are in mice. A study in humans looking at muscle protein synthesis (using an acute protocol of 30mg/kg bodyweight) found that the human supplement had no benefit, which was found to be due to a reduced effect of the Ostarine, since Arginine is thought to stimulate protein synthesis independently of its influence on protein breakdown (which is a result of it being an antioxidant or anti-oxidant).When analyzing muscle size in comparison to a control drug (vitamin A), a study in hypertrophic skeletal muscle from healthy persons (men or women) found that 20mg of Ostarine once daily without vitamin A for 6 months was able to preserve muscle mass (and strength) in the muscle of men with otherwise excellent physiques.Ostarine has claimed efficacy in a few rat studies but no conclusive results exist.3.2. CreatineSuffice it to say that the majority of studies suggest no significant influence on creatine synthesis from either Ostarine alone or Ostarine alongside Vitamin C, in comparison to another supplement (Amino Acids). Some supplemental Ostarine may be able to improve creatine kinase, as it is reduced by Vitamin C and Creatine when combined.3.3. Muscle DamageThe mechanism of Ostarine's effects on protein synthesis appears to be related to its effect on phosphorylation at MPSS1 and MPSS2 on both muscle fiber type I (myofibrillar), and type II (myofibrillar and sarcoplasmic)] where Ostarine supplementation (100mg/kg bodyweight) has demonstrated a moderate additive effect on the ability of a 60% reduction in phosphorylated MPS2 compared with Vitamin C and Amino Acids. This study noted an increase in the kinase activity for the phosphorylation of MPS2 at the sites implicated, as well as an alteration in phosphorylated mRNA for TNF, IL-6, and TNFb (not dissimilar from Ostarine itself).Although Ostarine has been investigated on its own on its role in inducing muscle damage, it isSimilar articles: